Basic Information
VIS ID
TVIS44021979
Fusion event
HTLV-1-THADA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
43607912/43380773 (Hg38)
End
43607912/43380773 (Hg38)
Orient
-
Location type
Intronic
Target gene
THADA
miRNAs that regulate target gene
hsa-mir-505-3p ; hsa-mir-106b-5p ; hsa-let-7e-5p
Nearest miRNA
hsa-mir-1301/Upstream/7909287; hsa-mir-10b/Downstream/3996902;
Nearest TSS
ENST00000437798/Upstream/8536; ENST00000460356/Downstream/11149;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/152961, chr2-CpG: 42/Downstream/215016
Upstream sequence
acccagtgccccaatcttggtttcgaataccattctccaataaaagaaaccaggtctccttggagaaatgactaattctatacctagaaaagggaacata
Downstream sequence
caaggtgagactagaacatcttgttccagaaaggaagaaaaatggctggatgcggtggctcacgcctgtaatcccagcactttgggaggctgaggtgggt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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