Basic Information
VIS ID
TVIS44021981
Fusion event
HTLV-1-PRKCE integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
46398341/46171202 (Hg38)
End
46398341/46171202 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
PRKCE
miRNAs that regulate target gene
hsa-mir-205-5p ; hsa-mir-1-3p ; hsa-mir-31-5p ; hsa-mir-96-5p ; hsa-mir-21-5p ; hsa-mir-342-3p ; hsa-mir-107 ; hsa-mir-146a-5p
Nearest miRNA
hsa-mir-1301/Upstream/10699716; hsa-mir-10b/Downstream/1206473;
Nearest TSS
ENST00000437798/Upstream/3224; ENST00000460015/Downstream/122465;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/518656, chr2-CpG: 289/Downstream/125448
Nearest cancer related gene
PRKCE(OG, No orient, 0)
Upstream sequence
TGCATCGCCAGGCTCGGGTCCTGCCACTGCACATCCTGCTGCGGGGGGCCAGCTCACTGCAGGGCCTGGCTCAGCAAGCTCAGGCCCCAGGCAAGCCAGG
Downstream sequence
GCAGGCAGGGTACTGTCTCCTCCTAAGGCTCTTTATTCCTGGATAGCCACACAGCATTTTCTACATCGTGTTCTGTCCCAGGCATCTCCTGGGGTGCCCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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