Basic Information
VIS ID
TVIS44022001
Fusion event
HTLV-1-ZNF638 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
71578194/71351064 (Hg38)
End
71578194/71351064 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
ZNF638
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-30a-5p ; hsa-mir-106b-3p ; hsa-mir-27a-3p ; hsa-mir-16-5p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-2355-5p ; hsa-mir-1236-3p ; hsa-mir-877-3p ; hsa-mir-6793-3p ; hsa-mir-141-5p ; hsa-mir-629-3p ; hsa-mir-6867-3p ; hsa-mir-4713-5p ; hsa-mir-642a-5p ; hsa-mir-4795-3p ; hsa-mir-6743-3p ; hsa-mir-942-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-6870-3p ; hsa-mir-216a-5p ; hsa-mir-302c-5p ; hsa-mir-665 ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-6078 ; hsa-mir-4768-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6878-3p ; hsa-mir-6735-3p ; hsa-mir-4324
Nearest miRNA
hsa-mir-1285-2/Upstream/1098059; hsa-mir-10b/Downstream/3739748;
Nearest TSS
ENST00000437798/Upstream/19282; ENST00000601581/Downstream/14365;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/18669, chr2-CpG: 64/Downstream/102364
Upstream sequence
GGCAGTGAAGTGTACTATAATGTAGAACATACTGTTCAGTCGTAATCATTGGTAGATTTGAGCAGGAATTTCCAAGTAAATTTTATTTACTTACGTATGG
Downstream sequence
TTGGCAATCACTGTTTCTTCTATTTACTAATGTGATTTATAGATTTAGATTGTAAAGGGTCAGAAGAGAATATACTAACATGGGAAAAAGCTTTGATTCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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