Basic Information
VIS ID
TVIS44022004
Fusion event
HTLV-1-RAB11FIP5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
73316233/73089105 (Hg38)
End
73316233/73089105 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
RAB11FIP5
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-7-5p ; hsa-mir-6776-3p ; hsa-mir-6760-3p ; hsa-mir-8485
Nearest miRNA
hsa-mir-1285-2/Upstream/2836100; hsa-mir-10b/Downstream/2001707;
Nearest TSS
ENST00000437798/Upstream/777; ENST00000398468/Downstream/550;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/17079, chr2-CpG: 149/Downstream/23059
Upstream sequence
CTGGGTCAGGGACGACTTGCGCAGCTTGTTGCGGAGGAAGAAGCCTTTGGCTTTGCCCATCTTGCCCAGGCTGCCCAGGTCAGGATCCTCTATGGCGCTG
Downstream sequence
CTTGGGAGGATGGCAGAGGCAGATTCCAGATCATACTTCTTCTTGCCCTTCATCTTGTCCCTGATCTTGCTGAAGGGAGACCTTGGCTTGTCCTTCATGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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