Basic Information
VIS ID
TVIS44022005
Fusion event
HTLV-1-SLC4A5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
74515185/74288058 (Hg38)
End
74515185/74288058 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
SLC4A5
Nearest miRNA
hsa-mir-1285-2/Upstream/4035053; hsa-mir-10b/Downstream/802754;
Nearest TSS
ENST00000437798/Upstream/37271; ENST00000416630/Downstream/2647;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/88762, chr2-CpG: 57/Downstream/103568
Upstream sequence
CATGGTCTCCATCTCCTCCTTGCCCAATCAGTTCCCGGCCTGCTGCCACTGGCTCAGCCCCCACCACGCTAAGGACATTGACAAAGGcagaggtttcaaa
Downstream sequence
ctgacagttcaaaggtgtgtttaattcaggcctcgcagagtatgaaattttttgaaagtattgctaagataaagaattgtaagatttcatatagaaatcc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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