Basic Information
VIS ID
TVIS44022026
Fusion event
HTLV-1-ASAP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
9533169/9393040 (Hg38)
End
9533169/9393040 (Hg38)
Orient
+
Location type
Intronic
Target gene
ASAP2
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-218-5p ; hsa-mir-4672 ; hsa-mir-3613-3p ; hsa-mir-6768-5p ; hsa-mir-618 ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p
Nearest miRNA
hsa-mir-7158/Upstream/2742601; hsa-mir-10b/Downstream/799574;
Nearest TSS
ENST00000437798/Upstream/4746; ENST00000484590/Downstream/5801;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/18174, chr2-CpG: 17/Downstream/403
Upstream sequence
gcctccttgtctgtaaaacgtagacactaaGAAAGCTCTTCACCCACCCACTCCGGAGACTGAGGAGCCGTTACTAAGTTAGTAGCTCCCATCTCTCCTC
Downstream sequence
AGATCCACCCTGCCCAGCAGCCCGATGAAGTGGGTAGGGCCTCATCCCTTTGGCCACAGGTCAGTCGATGTGCAAAGCAGGCCCTGCTTCCCCGGGCAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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