VISDB Viral Integration Site DataBase

VIS ID

TVIS44022029

Fusion event

HTLV-1-ADAM17 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

Virus name

HTLV-1

Reference genome

Not given

Chromosome

chr2

Cytoband

p25.1

Reference genome

Start

End

9659538/9519409 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-122-5p ; hsa-mir-145-5p ; hsa-mir-152-3p ; hsa-mir-26a-5p ; hsa-mir-218-5p ; hsa-mir-5697 ; hsa-mir-6882-5p ; hsa-mir-26b-5p ; hsa-mir-1297 ; hsa-mir-4465 ; hsa-mir-6731-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-5195-3p ; hsa-mir-129-5p ; hsa-mir-6842-3p ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-4284 ; hsa-mir-24-3p ; hsa-mir-5580-5p ; hsa-mir-6504-5p ; hsa-mir-3064-5p ; hsa-mir-149-5p ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-649 ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-6722-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-3691-3p ; hsa-mir-512-3p ; hsa-mir-6877-3p ; hsa-mir-6819-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-338-3p

Nearest miRNA

hsa-mir-7158/Upstream/2868970; hsa-mir-10b/Downstream/673205;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/44303, chr2-CpG: 97/Downstream/35984

Upstream sequence

TCTAAGAATATTCTAGGAGGCTTAGGGAAGAAAACTGGAGAGGACCATCTGTCAACATAAGTCATTTTTCTCTTTGGTTCCTCCCCTGCCATGGGCTGTC

Downstream sequence

TGGAGGCTCACAGAAAAGCAGACAGgcgcagtggttcagctgttctaggagtcaggagatctgtgctcaattcaacctctgccatcaccagttgtatgac