Basic Information
VIS ID
TVIS44022033
Fusion event
HTLV-1-MGAT4A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
99327295/98710832 (Hg38)
End
99327295/98710832 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2A
Target gene
MGAT4A
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-409-3p ; hsa-mir-376a-5p ; hsa-mir-4423-3p ; hsa-mir-376a-2-5p ; hsa-mir-3132 ; hsa-mir-197-5p ; hsa-mir-564 ; hsa-mir-3622a-5p ; hsa-mir-5582-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/1912479; hsa-mir-10b/Downstream/2598618;
Nearest TSS
ENST00000437798/Upstream/47359; ENST00000496794/Downstream/15864;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/101973, chr2-CpG: 150/Downstream/19587
Upstream sequence
attacaggcgtgagctactgtgcccagTAATTTTTTTCTGAATTTGAATAAGTAGAAGACAGTCAATACATTTGTTATTTCCTTCCTCTAATAAGTATGT
Downstream sequence
CTGCTTATATAGAAAATTTTGTCTATCTGTGTGTACAATAATGAAGGAAGGAAAAAGGAAGTTCTGTGCAAACCCACAGTTTTGGAGCAAAATAAGAAGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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