Basic Information
VIS ID
TVIS44022053
Fusion event
HTLV-1-PPARG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.2
Reference genome
GRCh37/hg19
Start
12351821/12310322 (Hg38)
End
12351821/12310322 (Hg38)
Orient
+
Location type
Intronic
Target gene
PPARG
miRNAs that regulate target gene
hsa-mir-20b-5p ; hsa-mir-27b-3p ; hsa-mir-138-5p ; hsa-mir-130a-3p ; hsa-mir-130b-3p ; hsa-mir-20a-5p ; hsa-mir-1-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-27a-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-12127/Upstream/1915760; hsa-let-7g/Downstream/3185917;
Nearest TSS
ENST00000440867/Upstream/4549; ENST00000477039/Downstream/2066;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/21488, chr3-CpG: 61/Downstream/173928
Nearest cancer related gene
PPARG(OG, No orient, 0)
Upstream sequence
TCCGACACTTGGGGCTACACACTAAGAATAGATACCAGTTTCTAGAAATCTTTACTTTTTGCCCATCTACTTCTGAAGAAATACCTATGTATTTCAAAGG
Downstream sequence
AAAATTGGCACAAGTATCAAGGAAAGCTGGTACAACTTAATCTTAACCTGGAATCAACTCCTTTAATTTTTACATACAGATTTGGTTCCGTTTTTTAGAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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