Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene123457017124080023124726325124091069124094552124089190124090405124075697124076780124084162124084992124082802124083567124078770124079320124053000124053160124043334124043343124091671
Basic Information
VIS ID
TVIS44022057
Fusion event
HTLV-1-KALRN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
123810518/124091671 (Hg38)
End
123810518/124091671 (Hg38)
Orient
-
Location type
Intronic
Target gene
KALRN
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-186-3p ; hsa-mir-5685 ; hsa-mir-4690-3p ; hsa-mir-5000-3p ; hsa-mir-4436a ; hsa-mir-8485 ; hsa-mir-1197 ; hsa-mir-329-3p ; hsa-mir-362-3p ; hsa-mir-6851-3p ; hsa-mir-5000-5p
Nearest miRNA
hsa-let-7g/Upstream/929792; hsa-mir-12124/Downstream/41258;
Nearest TSS
ENST00000440867/Upstream/11630; ENST00000488825/Downstream/2990;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/57319, chr3-CpG: 16/Downstream/177208
Nearby gene
KALRN(+3040) ;
Upstream sequence
AACATCGAAGAGAAAGGAACACATCCATGTTGTGATATCAAATAACTGCTGAACATCCGGATGGGCATCAGCCCTCTGGAGTGGATGGGCTGTTGCTGGC
Downstream sequence
CTGGTGTCACTGCCTGTCCCTGGAAAACATGTCTCTGTAGCCAGCTGGGTGGGCTGGAGGAAACACGTGAATGGGAATAGTTGTGCTTGCTTTGACCATG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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