Basic Information
VIS ID
TVIS44022060
Fusion event
HTLV-1-MGLL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
127452485/127733642 (Hg38)
End
127452485/127733642 (Hg38)
Orient
-
Location type
Intronic
Target gene
MGLL
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-30c-5p ; hsa-mir-142-3p ; hsa-mir-93-5p ; hsa-mir-205-5p ; hsa-mir-7151-5p ; hsa-mir-6886-3p ; hsa-mir-938 ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-4786-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-6761-5p ; hsa-mir-4329 ; hsa-mir-4251 ; hsa-mir-6728-3p ; hsa-mir-3200-5p ; hsa-mir-7855-5p ; hsa-mir-4766-3p ; hsa-mir-4733-5p ; hsa-mir-3908 ; hsa-mir-4703-5p ; hsa-mir-3942-5p ; hsa-mir-624-3p
Nearest miRNA
hsa-let-7g/Upstream/146466; hsa-mir-12124/Downstream/1113166;
Nearest TSS
ENST00000440867/Upstream/11072; ENST00000497045/Downstream/2715;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/60051, chr3-CpG: 89/Downstream/88785
Upstream sequence
GCAGATGCAGACCACTGGATGGGAGGAGAGGTGTCACTGTCTTGGGAGGACGTGGCCTGagaccatggtaaggatgctggcctctacctagagagagggg
Downstream sequence
aggctgaggagagttttaggcacaagagggatgtttgcattttttaaaaAATGGCCTCATTATATCACTGTCTCCACAAGATCATTATAGAAAAGTCTTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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