Basic Information
VIS ID
TVIS44022062
Fusion event
HTLV-1-EEFSEC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
127931731/128212888 (Hg38)
End
127931731/128212888 (Hg38)
Orient
-
Location type
Intronic
Target gene
EEFSEC
miRNAs that regulate target gene
hsa-mir-193b-3p
Nearest miRNA
hsa-let-7g/Upstream/625712; hsa-mir-12124/Downstream/633920;
Nearest TSS
ENST00000440867/Upstream/58974; ENST00000483569/Downstream/124016;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/58889, chr3-CpG: 45/Downstream/213526
Upstream sequence
gccaaagccaacatgatgaaatgaagcaagcataaaCAGGACGAGTGTTGCGAGTTCAAGCCGGCCACCAGCCTCCCCAGGCAGTGATGGGCTGGCGCTG
Downstream sequence
CCACATCAGCCAGCTCCTTCCAGGGCTGCCTTCCTGGGAGCATGGCAGCCACATCCCGGGGAGCAGCAGTCCTCTGCTAGCACACATCTGCAGCGCCAGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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