Basic Information
VIS ID
TVIS44022066
Fusion event
HTLV-1-COL6A6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
130265965/130547121 (Hg38)
End
130265965/130547121 (Hg38)
Orient
+
Location type
Intronic
Target gene
COL6A6
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-let-7g/Upstream/1274878; hsa-mir-1224/Downstream/1438734;
Nearest TSS
ENST00000440867/Upstream/103637; ENST00000511332/Downstream/13213;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/29762, chr3-CpG: 21/Downstream/199513
Nearby gene
COL6A6(+13213) ;
Upstream sequence
ggcagcaggtggagctgcccgccagtcctgcgcggcctgcctgcactcctcagcccttgggcggttgatgcgacctggcgccacagagcagggggcgacg
Downstream sequence
cccatctgggaggtttgggccacgaggcagccgactgcggaggggctcgggcatggcaggctgcaggtcccgagccatgccccgcagggaggtggctgag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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