Basic Information
VIS ID
TVIS44022069
Fusion event
HTLV-1-TMEM108 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
133110527/133391683 (Hg38)
End
133110527/133391683 (Hg38)
Orient
-
Location type
Intronic
Target gene
TMEM108
miRNAs that regulate target gene
hsa-mir-183-5p
Nearest miRNA
hsa-let-7g/Upstream/1405752; hsa-mir-1224/Downstream/976121;
Nearest TSS
ENST00000440867/Upstream/11966; ENST00000513441/Downstream/8312;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/352632, chr3-CpG: 151/Downstream/181676
Upstream sequence
cccatcttttgctaagctccagccacactggatttctttttgttccttcacagcaccaggttacatcacacccactccaggtgtgtgcatgggctgtcgc
Downstream sequence
ctctcctacaacatcttcaggctctccccagcacccccttcacttgctcacctcagtgactccaacccatcctgctgcagggcccagtctaaatgtcact
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate