Basic Information
VIS ID
TVIS44022075
Fusion event
HTLV-1-PXYLP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q23
Reference genome
GRCh37/hg19
Start
140977146/141258304 (Hg38)
End
140977146/141258304 (Hg38)
Orient
-
Location type
Intronic
Target gene
PXYLP1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-130b-3p ; hsa-mir-93-5p ; hsa-mir-19b-3p
Nearest miRNA
hsa-let-7g/Upstream/6820398; hsa-mir-1224/Downstream/10307572;
Nearest TSS
ENST00000440867/Upstream/26390; ENST00000512457/Downstream/1819;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/25695, chr3-CpG: 29/Downstream/53352
Upstream sequence
CCAGGGCCAGCACAGTGGCTTCCCAGGCCCAGAGTGAGAGGCCTGAAGACAAGATTTGCACCAGAGCTGCAGAGGGAGGGATGTGCAGGAGAACATGTGT
Downstream sequence
ACGTGTAGTACTGAGCTTCGGGCACGGAGGCACTGACTCTCGGTTAGGGATAGTGACTCATGGGACAGAAGCGTTTCCCTCAAGCTCTTCCTTTCCATCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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