Basic Information
VIS ID
TVIS44022091
Fusion event
HTLV-1-METTL6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
15434727/15393220 (Hg38)
End
15434727/15393220 (Hg38)
Orient
-
Location type
Intronic
Target gene
METTL6
miRNAs that regulate target gene
hsa-let-7a-5p ; hsa-mir-7109-5p ; hsa-mir-6085 ; hsa-mir-4665-5p ; hsa-mir-1275 ; hsa-mir-6824-5p ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-6870-5p ; hsa-mir-7111-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-625-5p ; hsa-mir-6825-5p ; hsa-mir-3175 ; hsa-mir-7106-5p ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-765 ; hsa-mir-4784 ; hsa-mir-4731-5p ; hsa-mir-3150b-3p ; hsa-mir-637 ; hsa-mir-6783-5p
Nearest miRNA
hsa-mir-12127/Upstream/4998658; hsa-let-7g/Downstream/103019;
Nearest TSS
ENST00000440867/Upstream/51852; ENST00000449565/Downstream/6271;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/60518, chr3-CpG: 46/Downstream/34205
Nearby gene
METTL6(-16540) ;
Upstream sequence
acccatgaacatggaatgttcttccatttgtttgtatcctcttctattacattgagcagtggttgtagttctccttgaagaggtccttcacgtcccttgt
Downstream sequence
aagttggattcctaggtatttcattctctttgaagcaattgtgaatgggagttcactcatgatttggctctctgtttgtctgttattggtgtataagaat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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