Basic Information
VIS ID
TVIS44022093
Fusion event
HTLV-1-KCNAB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q25.31
Reference genome
GRCh37/hg19
Start
156006972/156289183 (Hg38)
End
156006972/156289183 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
KCNAB1
miRNAs that regulate target gene
hsa-mir-578 ; hsa-mir-526b-5p ; hsa-mir-144-5p ; hsa-mir-3613-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-4282 ; hsa-mir-3606-3p
Nearest miRNA
hsa-let-7g/Upstream/4723188; hsa-mir-1224/Downstream/2993463;
Nearest TSS
ENST00000440867/Upstream/15630; ENST00000496923/Downstream/1804;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/417370, chr3-CpG: 29/Downstream/2019
Upstream sequence
aatAACCTACTCCCTGTTCTGCTGTTGGTTGTGCTTTCAGAAATTGCTCTGCTAGTTCTTGGCAAGGCTGAAAGCCACTTCAGCTAACAGCATCCAGACC
Downstream sequence
TTCCCTACCTTCAAGATCTTCTGTCCTCCCTGTGGAACTGACAGCACTCCACCTCATCTCTGAGCCCCCCACACATCTCCTCAAGCTCAGCCAGTGTCCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate