Basic Information
VIS ID
TVIS44022126
Fusion event
HTLV-1-MUC4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q29
Reference genome
GRCh37/hg19
Start
195511086/195784215 (Hg38)
End
195511086/195784215 (Hg38)
Orient
-
Location type
Exonic
Target gene
MUC4
miRNAs that regulate target gene
hsa-mir-150-5p ; hsa-mir-335-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-3180-5p ; hsa-mir-378a-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-2277-3p ; hsa-mir-4526 ; hsa-mir-3660 ; hsa-mir-6734-3p ; hsa-mir-6832-3p ; hsa-mir-4704-3p ; hsa-mir-3614-3p ; hsa-mir-219a-1-3p
Nearest miRNA
hsa-let-7g/Upstream/84718; hsa-mir-4797/Downstream/98114;
Nearest TSS
ENST00000440867/Upstream/5405; ENST00000458180/Downstream/27642;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/21143, chr3-CpG: 27/Downstream/53661
Nearest cancer related gene
MUC4(OG, No orient, 0)
Upstream sequence
TGACGAAGCGTCGGTGACAAGAAGAGGGGTGGTGTGACCTGTGGATACTGAGGAAGTGTCGGTGCCAGGAAGAGGGGTGGTGTCACCTGTGGATGCTGAG
Downstream sequence
GAAGTGCTGGTGACAGGAAGAGGGGTGGCATGACCTGTGGATGCCGAGGAAACGTTGGTGACAGGAAGACGGGTGGTGTCACCTGTGGAAGCTGAGGAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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