Basic Information
VIS ID
TVIS44022137
Fusion event
HTLV-1-SLC4A7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
27441473/27399982 (Hg38)
End
27441473/27399982 (Hg38)
Orient
-
Location type
Intronic
Target gene
SLC4A7
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-34a-5p ; hsa-mir-19b-3p ; hsa-mir-25-3p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-12127/Upstream/1735043; hsa-let-7g/Downstream/3761722;
Nearest TSS
ENST00000440867/Upstream/8137; ENST00000607601/Downstream/1062;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/30407, chr3-CpG: 132/Downstream/83461
Upstream sequence
ttaattaatcttaagtttaaatagacacacgtggctaatggctactgtattggacaatacagTCTTAAATTATCAGTGGGATAAAATTTCAGATAATATC
Downstream sequence
CTTCAAATTATATAGTTAGGAACTATCACCTTTAGTGAGAAAGGAATGACCTACAGTTACTTATATGATATAAAAAGCACAACGGTAGCTCAAGGGATCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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