Basic Information
VIS ID
TVIS44022147
Fusion event
HTLV-1-ITGA9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
37630178/37588687 (Hg38)
End
37630178/37588687 (Hg38)
Orient
-
Location type
Intronic
Target gene
ITGA9
miRNAs that regulate target gene
hsa-mir-194-5p ; hsa-mir-484 ; hsa-mir-452-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-452-3p ; hsa-mir-6794-3p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-759 ; hsa-mir-4639-3p ; hsa-mir-5000-5p ; hsa-mir-125b-1-3p
Nearest miRNA
hsa-mir-12127/Upstream/1844128; hsa-let-7g/Downstream/380717;
Nearest TSS
ENST00000440867/Upstream/136568; ENST00000461533/Downstream/95189;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/135640, chr3-CpG: 203/Downstream/271760
Upstream sequence
gagggagATGTGGAGACTGAccttggtctcacaaactcattgccccttgcaaagaaataaccaggagggtctcctgagaatggggttcagagtaagggcc
Downstream sequence
cctcttgcctgggtcttacccagggtgatacCATTTCTGCCAAGTCAGAGGATGAAAGGGACTTCGGCGGAAGCCATATGACCCACCTCTGTCATTTTAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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