Basic Information
VIS ID
TVIS44022155
Fusion event
HTLV-1-SNRK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
43348708/43307216 (Hg38)
End
43348708/43307216 (Hg38)
Orient
+
Location type
Intronic
Target gene
SNRK
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-21-5p ; hsa-mir-193b-3p ; hsa-mir-192-3p ; hsa-mir-365a-3p ; hsa-mir-365b-3p ; hsa-mir-938 ; hsa-mir-3065-5p ; hsa-mir-4772-3p ; hsa-mir-6886-3p ; hsa-mir-942-5p ; hsa-mir-4768-5p ; hsa-mir-6833-3p ; hsa-mir-340-5p ; hsa-mir-4789-5p ; hsa-mir-4789-3p ; hsa-mir-5011-5p ; hsa-mir-137 ; hsa-mir-6873-3p ; hsa-mir-6845-3p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-944 ; hsa-mir-6809-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-1251-5p ; hsa-mir-517-5p ; hsa-mir-153-5p ; hsa-mir-154-5p ; hsa-mir-4422
Nearest miRNA
hsa-mir-12127/Upstream/4168950; hsa-let-7g/Downstream/806996;
Nearest TSS
ENST00000440867/Upstream/4104; ENST00000484791/Downstream/24950;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/20502, chr3-CpG: 18/Downstream/56711
Upstream sequence
tggtagtcttctattctcatctgtgaattttgtaatttaaccattttttgctttatacatggtattgtcaagctataattgacaataaagatattaaaag
Downstream sequence
tttctaatatattttacatgatgagttataccttttatcaatacgaaagtatactccttgatacatattgccttaaattctgttttgtcATTGCTTTAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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