Basic Information
VIS ID
TVIS44022164
Fusion event
HTLV-1-ITPR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p26.1
Reference genome
GRCh37/hg19
Start
4798731/4757047 (Hg38)
End
4798731/4757047 (Hg38)
Orient
+
Location type
Intronic
Target gene
ITPR1
miRNAs that regulate target gene
hsa-mir-424-5p ; hsa-mir-335-5p ; hsa-mir-340-5p ; hsa-mir-128-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-92a-3p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-92b-3p ; hsa-mir-4328 ; hsa-mir-4803 ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-204-5p ; hsa-mir-211-5p ; hsa-mir-494-3p ; hsa-mir-34c-5p ; hsa-mir-34b-3p ; hsa-mir-449a ; hsa-mir-448 ; hsa-mir-3163
Nearest miRNA
hsa-let-7g/Downstream/493130;
Nearest TSS
ENST00000440867/Upstream/5457; ENST00000479831/Downstream/11220;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/263364, chr3-CpG: 67/Downstream/111231
Upstream sequence
tttttcacacctactgtttcataacaaccttgctgggtgggccccagcttccatgtgatgctgacatggcaggtggtaagaccctcattttttagctaaa
Downstream sequence
gaacccagggcacaaatgaagttaagtaaattgcccacaatcacatggctggatagcaaggagccaaggccaaaatgtaggtttcccgagttccagttct
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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