Basic Information
VIS ID
TVIS44022167
Fusion event
HTLV-1-CACNA2D2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
50421605/50384174 (Hg38)
End
50421605/50384174 (Hg38)
Orient
-
Location type
Intronic
Target gene
CACNA2D2
miRNAs that regulate target gene
hsa-mir-6774-5p ; hsa-mir-328-5p ; hsa-mir-3151-5p ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-486-3p ; hsa-mir-6721-5p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-4668-5p ; hsa-mir-6804-5p ; hsa-mir-4459 ; hsa-mir-4779 ; hsa-mir-4484
Nearest miRNA
hsa-mir-12127/Upstream/110877; hsa-let-7g/Downstream/290906;
Nearest TSS
ENST00000440867/Upstream/16709; ENST00000424388/Downstream/119249;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/18663, chr3-CpG: 101/Downstream/118615
Upstream sequence
TGTAGGAGGCTGGAGGTAGATGGCACTGGCCTTCTGTCCCCAGGGACTCTGGAATGCCCTGGCAGTGGGCCTGCCCCCACAGCAGGTGGGATGGGCTGTC
Downstream sequence
CCGATTGCTCTGCACACTCACAGCCTTTGTAGATGTCCGTAGGGATCTGTACAGCCGCGTATGAATAGTTGACCTTGTTCTTGAAGTTTGGGTCCTCGAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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