Basic Information
VIS ID
TVIS44022171
Fusion event
HTLV-1-ARHGEF3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
56865582/56831554 (Hg38)
End
56865582/56831554 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARHGEF3
miRNAs that regulate target gene
hsa-mir-138-5p ; hsa-mir-373-3p ; hsa-mir-335-5p ; hsa-mir-769-5p ; hsa-mir-377-5p ; hsa-mir-485-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-889-3p ; hsa-mir-4793-5p ; hsa-mir-5196-3p
Nearest miRNA
hsa-let-7g/Upstream/978960; hsa-mir-12124/Downstream/3786251;
Nearest TSS
ENST00000440867/Upstream/29587; ENST00000495939/Downstream/84917;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/29372, chr3-CpG: 112/Downstream/247167
Upstream sequence
tctaattgttttaggttttgtggactattcagtctctgttgcaactattcacctctgccaatgcaatataaaagcagccactgacaataaataaataaca
Downstream sequence
gtgtggttgtgttacaataaaaccttatttacaaaagcagacagtgggccattcttggcTACAGTTTGCTGGCATCTACACTAGACCACTGGAGAAGCAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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