Basic Information
VIS ID
TVIS44022172
Fusion event
HTLV-1-FAM107A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
58577177/58591450 (Hg38)
End
58577177/58591450 (Hg38)
Orient
-
Location type
Intronic
Target gene
FAM107A
miRNAs that regulate target gene
hsa-mir-342-3p ; hsa-mir-4530 ; hsa-mir-1226-3p ; hsa-mir-1228-3p ; hsa-mir-634 ; hsa-mir-4282 ; hsa-mir-129-5p ; hsa-mir-874-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-6826-3p ; hsa-mir-346 ; hsa-mir-6886-3p ; hsa-mir-938 ; hsa-mir-146b-3p ; hsa-mir-6799-3p ; hsa-mir-3173-5p ; hsa-mir-7976 ; hsa-mir-18a-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-3667-3p ; hsa-mir-6752-3p ; hsa-mir-6795-3p ; hsa-mir-6887-3p ; hsa-mir-219b-3p ; hsa-mir-6069
Nearest miRNA
hsa-let-7g/Upstream/2738856; hsa-mir-12124/Downstream/2026355;
Nearest TSS
ENST00000440867/Upstream/4337; ENST00000464125/Downstream/15630;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/4274, chr3-CpG: 57/Downstream/458230
Upstream sequence
ctggggcagggtcagcggttaatgcaaaggttccgagctgggctgtgcccggcatattcaggagcagcaaggaggtcagggtggccgaagtggagggaac
Downstream sequence
actggggcagtcacatgagagaaggtcagtgaggagacaggggccaacttcctccatgcctcatactccaaccactgagaactctctgggttccctgaaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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