Basic Information
VIS ID
TVIS44022179
Fusion event
HTLV-1-GRM7-AS3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p26.1
Reference genome
GRCh37/hg19
Start
6846073/6804386 (Hg38)
End
6846073/6804386 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
GRM7-AS3
Nearest miRNA
hsa-mir-4790/Upstream/1554131; hsa-let-7g/Downstream/3475965;
Nearest TSS
ENST00000440867/Upstream/13281; ENST00000435689/Downstream/1023;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1615881, chr3-CpG: 71/Downstream/56750
Upstream sequence
AGCCTGAAATGCAGGATAAAAGGGAGGATATTGTTTGCTTTAACAAACTGAAATTTTGGTGTGAAAGAGAAGCAGGCCCTTGAAAATATTCCTTTGTTGG
Downstream sequence
TATGAATCAAGGAATTGAGGTTGTAATTTCAAATTTTACCAAGGACAGTGTGAGAATGAAGATTAATCTTCCAGCAAAAAAGAACTGTTCTCTGTTTTGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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