Basic Information
VIS ID
TVIS44022214
Fusion event
HTLV-1-MANBA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q24
Reference genome
GRCh37/hg19
Start
103656328/102735171 (Hg38)
End
103656328/102735171 (Hg38)
Orient
+
Location type
Intronic
Target gene
MANBA
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-12113/Upstream/1404757; hsa-mir-1243/Downstream/6753527;
Nearest TSS
ENST00000502981/Upstream/6565; ENST00000501133/Downstream/25762;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/233099, chr4-CpG: 54/Downstream/25508
Upstream sequence
CCAGGCCTCACCTGTTTGTTTAGGCCAAAACGCCATGGCCATGCAATGTTAGTGATCCCACTAGCTGCGACAGCCAGGCCCAGAAAATGCCTGACATGAG
Downstream sequence
AGCCAGCAGACAGCCCAGGCCAGGGTAGGCAGTGCCTGCTTCTGCTCTATCAGGTGCAAGGGATTTGGCTGAAGGCATGCATATTTCCTGGACACAAACT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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