Basic Information
VIS ID
TVIS44022238
Fusion event
HTLV-1-MGST2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
140629629/139708475 (Hg38)
End
140629629/139708475 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4C
Target gene
MGST2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-30a-5p ; hsa-mir-340-3p ; hsa-mir-106a-5p
Nearest miRNA
hsa-mir-12113/Upstream/14201168; hsa-mir-1305/Downstream/3634985;
Nearest TSS
ENST00000502981/Upstream/42447; ENST00000509184/Downstream/181577;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/9849, chr4-CpG: 96/Downstream/26333
Upstream sequence
tatgcggcattatttctgagggctctgttctgttccattgatctatatctcttttttggtaccagtaccatgctgttttgttgactgtagccttgtagta
Downstream sequence
tagtttgaagtcaggtatcgtgatgcctccggctttgttcttttggcttaggattgacttggtgatgtgggctcttttttggttccatatgaactttaaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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