Basic Information
VIS ID
TVIS44022249
Fusion event
HTLV-1-GATB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
152627625/151706473 (Hg38)
End
152627625/151706473 (Hg38)
Orient
-
Location type
Intronic
Target gene
GATB
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-let-7e-5p
Nearest miRNA
hsa-mir-12113/Upstream/3923805; hsa-mir-1305/Downstream/782854;
Nearest TSS
ENST00000502981/Upstream/4955; ENST00000513617/Downstream/9771;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/296752, chr4-CpG: 21/Downstream/54416
Upstream sequence
TTTTTTAAGGTTACCATCaccacctcttaaaataacgggtcccagcccactacctacagggggaggtggaacttcctccatttgttccaggcttcctcct
Downstream sequence
caCCAACTTGGCTTATAAGGGTTTTCCCTGACTCAAACCTTTCATGGCTTTGGGAACATGGGCTATGTCCCTTTCCGGATGCAGAACAGTTCACCATCTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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