Basic Information
VIS ID
TVIS44022268
Fusion event
HTLV-1-ENPP6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
185040073/184118920 (Hg38)
End
185040073/184118920 (Hg38)
Orient
-
Location type
Intronic
Target gene
ENPP6
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-3622b-5p ; hsa-mir-5000-3p ; hsa-mir-4436a ; hsa-mir-506-5p ; hsa-mir-6512-5p ; hsa-mir-4666a-5p ; hsa-mir-8068 ; hsa-mir-143-5p ; hsa-mir-5087 ; hsa-mir-3944-5p ; hsa-mir-657 ; hsa-mir-3665 ; hsa-mir-298 ; hsa-mir-4748 ; hsa-mir-4464 ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-1283 ; hsa-mir-4714-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-4282
Nearest miRNA
hsa-mir-12113/Upstream/1949542; hsa-mir-3945/Downstream/732093;
Nearest TSS
ENST00000502981/Upstream/1099; ENST00000509538/Downstream/98782;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/21352, chr4-CpG: 27/Downstream/49614
Upstream sequence
GCTCTAAGGTCCAGGAACCATTCTAGAAGGACATGTGGCCCCCAGCACAGTCACCTGAGAGCTGCAAGGGGTTCCTAGCCCTGGGGTTTCAGGGACACCT
Downstream sequence
GAGTCTCCCATCACCTTATGATTCTGTCCTGATTTCTTTGCCATGTAAAAAGTTCTTAATGTTCTTTCCATTTTTCTTACTAAAGTGGCTGACtgttaag
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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