Basic Information
VIS ID
TVIS44022281
Fusion event
HTLV-1-MIR548AJ2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
23463713/23462090 (Hg38)
End
23463713/23462090 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA4D
Target gene
MIR548AJ2
Nearest miRNA
hsa-mir-12113/Upstream/946705; hsa-mir-1243/Downstream/1058102;
Nearest TSS
ENST00000502981/Upstream/176517; ENST00000499715/Downstream/98833;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/945665, chr4-CpG: 266/Downstream/1007987
Upstream sequence
TTTGTGGGGAAAGAAAAACAAGTTAATATTGTTTGACTTTGAGTTAGCTAAAATCTGGAAGGACTTCCTAGGTGAATTTGTCTGGCAGATAGAGAGAAGG
Downstream sequence
TTAGGACACAGGTCTGGATGAAAGATAGTGACTGAAAATTCACTCCCAACAAGGCTGAGGATCCAATGACAGTGTAATATGTTTAAGAGGAAAGAGGGCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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