Basic Information
VIS ID
TVIS44022295
Fusion event
HTLV-1-APBB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p14
Reference genome
GRCh37/hg19
Start
40835543/40833526 (Hg38)
End
40835543/40833526 (Hg38)
Orient
-
Location type
Intronic
Target gene
APBB2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p ; hsa-mir-9-5p ; hsa-mir-26b-5p ; hsa-mir-424-5p ; hsa-mir-93-5p ; hsa-mir-27a-3p ; hsa-mir-1260b ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-1224-5p ; hsa-mir-3915 ; hsa-mir-526b-5p ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-3116 ; hsa-mir-1254 ; hsa-mir-3663-3p ; hsa-mir-4638-3p ; hsa-mir-3690 ; hsa-mir-942-3p
Nearest miRNA
hsa-mir-12113/Upstream/331407; hsa-mir-1243/Downstream/6819143;
Nearest TSS
ENST00000502981/Upstream/3011; ENST00000514924/Downstream/8990;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/82647, chr4-CpG: 40/Downstream/23341
Upstream sequence
CTGTCCAGCGCACGCCCATCTACTCAGCCTAGCCCAGCTCAACGGTCCGCCTGGTCCTCTGGCCCCAGGACCCTGCTTGTATCAAAATGCCCACGGTATT
Downstream sequence
TACATTCTGTGCTACAAAGAAGAGGTCGTTATATCATACCTTTTTGTAGTTACTGTTACAGGTGTCACCTGTGTCTGTCCTCTAAGAGACAGCAGCAGCc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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