Basic Information
VIS ID
TVIS44022336
Fusion event
HTLV-1-FGF5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q21.21
Reference genome
GRCh37/hg19
Start
81206748/80285594 (Hg38)
End
81206748/80285594 (Hg38)
Orient
-
Location type
Intronic
Target gene
FGF5
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-15b-5p ; hsa-mir-3662 ; hsa-mir-7156-3p ; hsa-mir-6516-3p ; hsa-mir-1206 ; hsa-mir-1272 ; hsa-mir-8084 ; hsa-mir-6802-5p ; hsa-mir-6716-5p ; hsa-mir-6865-5p ; hsa-mir-6815-5p ; hsa-mir-4643 ; hsa-mir-4511 ; hsa-mir-548b-3p ; hsa-mir-3149 ; hsa-mir-297 ; hsa-mir-675-3p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-3613-3p ; hsa-mir-548c-3p ; hsa-mir-4435 ; hsa-mir-188-5p ; hsa-let-7b-3p
Nearest miRNA
hsa-mir-12113/Upstream/3709968; hsa-mir-1243/Downstream/2467743;
Nearest TSS
ENST00000502981/Upstream/17329; ENST00000503883/Downstream/50126;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/18835, chr4-CpG: 33/Downstream/50292
Nearest cancer related gene
FGF5(OG, No orient, 0)
Upstream sequence
tcttggccacctccaccctcttagatgcccttcctctatgctgtcattgtaccctctgcataccgctgtcataattccatttatcaagctgcaccatgac
Downstream sequence
ggatgtctacttgtctgcttttccactattctgtaagcatttcaagggcagatattttgtGTGTGTGTAAGATCTGGCCAAAGTGTAGTTAGTAACTCGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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