Basic Information
VIS ID
TVIS44022338
Fusion event
HTLV-1-HTRA3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
8281961/8280234 (Hg38)
End
8281961/8280234 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
HTRA3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p
Nearest miRNA
hsa-mir-378d-1/Upstream/274853; hsa-mir-12113/Downstream/1275934;
Nearest TSS
ENST00000502981/Upstream/10457; ENST00000509453/Downstream/39883;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/9870, chr4-CpG: 27/Downstream/25763
Nearest cancer related gene
HTRA3(TSG, No orient, 0)
Upstream sequence
AGAAACTGGAGTTGGTGGCCCGACAAAGGCCACACGGTAGGAGAGGTAATATGGTCCCACCTGGGGGCTGTGCCCGTGCCCTGGCGCTTCTCCTCAGGCG
Downstream sequence
AGGCACATGGGGCGCCAGCCTCAGGCCCCAGGGCACACAGGGGAGCAGCAGACCGGCTGAGTCCTCCCTCCTGGAGGGAGGAGGGCCTGGGCCTGGGGGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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