Basic Information
VIS ID
TVIS44022343
Fusion event
HTLV-1-PPM1K-DT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
89228864/88307712 (Hg38)
End
89228864/88307712 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
PPM1K-DT
Nearest miRNA
hsa-mir-12113/Upstream/1007129; hsa-mir-1243/Downstream/10689675;
Nearest TSS
ENST00000502981/Upstream/22770; ENST00000504905/Downstream/71027;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/22795, chr4-CpG: 29/Downstream/71126
Nearby gene
PPM1K(-22881) ;
Upstream sequence
gtaacaaatacaaagtttaaaaagggaacatatgaggtaaaattaatagcaatatgacaatcccagtttgcataatggttttgagccataaacctaggct
Downstream sequence
taaaggcacccaattaaataaatcaaatgaccatTATCCTGTCAAGTGAAAGCAAAAACTGCAGCCTTGCACAAAGGCCAactcaggagactgaggtggg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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