Basic Information
VIS ID
TVIS44022344
Fusion event
HTLV-1-HMX1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
8847935/8846209 (Hg38)
End
8847935/8846209 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA4A
Target gene
HMX1
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-211-5p ; hsa-mir-7847-3p ; hsa-mir-3141 ; hsa-mir-6880-5p ; hsa-mir-6745 ; hsa-mir-363-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-6827-5p ; hsa-mir-765 ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-766-5p ; hsa-mir-3656 ; hsa-mir-6889-5p ; hsa-mir-3195 ; hsa-mir-6777-5p ; hsa-mir-4779 ; hsa-mir-1180-5p ; hsa-mir-3649 ; hsa-mir-3690 ; hsa-mir-4254 ; hsa-mir-4268 ; hsa-mir-4448 ; hsa-mir-6772-3p ; hsa-mir-7114-3p ; hsa-mir-711
Nearest miRNA
hsa-mir-378d-1/Upstream/840828; hsa-mir-12113/Downstream/709959;
Nearest TSS
ENST00000502981/Upstream/100176; ENST00000512047/Downstream/25413;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/98339, chr4-CpG: 354/Downstream/11002
Upstream sequence
actgagtgccccctgtgggaacactgctccacgcggtcactcgggggtccaggctgacaaaggctccaccgtgttgtggctgcaccatccagtccctgcg
Downstream sequence
gcctcCTCCGCCATCCAGAGGCTCCCACTGTCACTTCTGTTCACTTTGTATTTATCAGCTCTGGTCACCTGCCCCTCTCCACACTGCACAGGCTGAGGTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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