Basic Information
VIS ID
TVIS44022345
Fusion event
HTLV-1-HERC3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
89539097/88617946 (Hg38)
End
89539097/88617946 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
HERC3
miRNAs that regulate target gene
hsa-mir-181a-5p ; hsa-mir-23b-3p
Nearest miRNA
hsa-mir-12113/Upstream/1317363; hsa-mir-1243/Downstream/10379441;
Nearest TSS
ENST00000502981/Upstream/12152; ENST00000504994/Downstream/40322;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/24616, chr4-CpG: 26/Downstream/79667
Upstream sequence
ggcgacacagcgagactccgtctaaaggaaaaaaaaagaaaaaaaaaaCAGGGAGTGCAGAAAAGTGGGGACCATTATGCCCTTAGGCAGCAAGTCCCCT
Downstream sequence
GGTTTCCCTCAAGGAAGTGGAGGCAGCAGGCAGGCAGTGAATGCTGGGTCTCCTCCAGGACGAGCTGGAAGCGAGGATGTTGAGAAAAAGCTGGAGAGAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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