Basic Information
VIS ID
TVIS44022347
Fusion event
HTLV-1-GAK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
915399/921611 (Hg38)
End
915399/921611 (Hg38)
Orient
-
Location type
Intronic
Target gene
GAK
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-744-5p ; hsa-mir-301a-3p ; hsa-mir-92a-3p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-93-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-571/Upstream/571359; hsa-mir-12113/Downstream/1064773;
Nearest TSS
ENST00000502981/Upstream/5855; ENST00000504850/Downstream/10576;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/6359, chr4-CpG: 88/Downstream/5207
Upstream sequence
cggacataaatctgcaactgtgaaggtttaaaactttcagaaaaacacaggagacaaatcttcaagataaagagctaagaatccttagctgtgacaaggc
Downstream sequence
gtgattcgtaaaaggaaaaataaatcagacttcacaatgaaaaactttggatctgcaacagaccccgctttgtttgttttttttttttaattaactggtc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate