Basic Information
VIS ID
TVIS44022349
Fusion event
HTLV-1-GRID2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
94728265/93807114 (Hg38)
End
94728265/93807114 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
GRID2
miRNAs that regulate target gene
hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-448
Nearest miRNA
hsa-mir-12113/Upstream/6506531; hsa-mir-1243/Downstream/5190273;
Nearest TSS
ENST00000502981/Upstream/37884; ENST00000306011/Downstream/21639;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1501258, chr4-CpG: 112/Downstream/21230
Nearby gene
ATOH1(+21813) ;
Upstream sequence
CCAGATTGTGACACACAGAAATCCTTGCTGTAATCCACTCATAGAAGAGTAACGACAGGACTGCTGCTTTCAGCCACAGGTCATGGATCTTGCCTGCGCC
Downstream sequence
AGCCCATTAGCCTTAGAAGGATGCTTCTATGCAGTGGACTTCTTGCCTAGATGTCCTGGTCAAGAGCACTCACACTGAGGTCCAAGTCTATACCACAGTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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