Basic Information
VIS ID
TVIS44022351
Fusion event
HTLV-1-UNC5C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
96308787/95387636 (Hg38)
End
96308787/95387636 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
UNC5C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-4477b ; hsa-mir-488-3p ; hsa-mir-4496 ; hsa-mir-323a-3p ; hsa-mir-651-3p ; hsa-mir-6762-3p ; hsa-mir-93-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-500a-5p ; hsa-mir-222-5p ; hsa-mir-6806-5p ; hsa-mir-5088-3p ; hsa-mir-3129-5p ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-936
Nearest miRNA
hsa-mir-12113/Upstream/8087053; hsa-mir-1243/Downstream/3609751;
Nearest TSS
ENST00000502981/Upstream/52004; ENST00000605849/Downstream/161336;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/628978, chr4-CpG: 20/Downstream/160669
Nearest cancer related gene
UNC5C(TSG, No orient, 0)
Upstream sequence
TTCACTTTTAAAATGTAATAAGGGCTCTGAAATTCTATCCACATGGAGGGCTAACAACTCAATACTAAAGGTTTTTAAAATAATGCATAATTCATCCTAA
Downstream sequence
AACTCTGTGTTTCTATGACTGCTGTCCCATGAACTTTTGTAATCTGCCAGTGCAAAAAACAAAGTAAGATTTTTTTCTTTTTGCCTGTAATAATACATCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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