Basic Information
VIS ID
TVIS44022354
Fusion event
HTLV-1-ST8SIA4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
100205121/100869417 (Hg38)
End
100205121/100869417 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5F
Target gene
ST8SIA4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-8485 ; hsa-mir-135a-5p ; hsa-mir-3140-3p ; hsa-mir-4776-3p ; hsa-mir-487b-5p ; hsa-mir-487a-5p ; hsa-mir-4659b-5p ; hsa-mir-4659a-5p ; hsa-mir-5590-5p ; hsa-mir-664a-3p ; hsa-mir-26a-5p ; hsa-mir-26b-5p ; hsa-mir-181c-5p
Nearest miRNA
hsa-mir-10397/Upstream/52852; hsa-mir-103a-1/Downstream/9644412;
Nearest TSS
ENST00000502646/Upstream/211447; ENST00000506058/Downstream/21465;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/333401, chr5-CpG: 32/Downstream/31446
Upstream sequence
AATCAAAAACTCTAGCCATATTTTGGAAATCTATAGAAGGATAGATCTACCGACCATTTGCTAATGTCCATTTCATGTCAAAGACAGATAACAATGATAA
Downstream sequence
CATTTCACATTAATATGAATCATACCATCGACACTAGGTGTTATCATCTTACTTTCTGCTATGATCTGAATGTCATCACTTTTTTCCTCCTCTAATATCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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