Basic Information
VIS ID
TVIS44022382
Fusion event
HTLV-1-chr5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
131834081/132498389 (Hg38)
End
131834081/132498389 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA5C
Nearest miRNA
hsa-mir-10397/Upstream/132790; hsa-mir-103a-1/Downstream/929207;
Nearest TSS
ENST00000502646/Upstream/7591; ENST00000416135/Downstream/45133;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1187, chr5-CpG: 43/Downstream/58483
Nearby gene
IRF1(-7616) ;
Nearest cancer related gene
IRF1(TSG, -7616) ;
Upstream sequence
CCCTGTATGGGCCAACACTGACTTTCACCAGCCCAGGCTTAGGATCAGGGTGGCTGGCCTGGGAGAGGGCCAGGGAAAGTCCAAATACTGCAAGAGTGGA
Downstream sequence
GCTTGTGCCATGAGCGCCTGGCAACCCTGGTGACTCAACCTGGGAATCCCAACTCCAGGGGCAGCCCTGGAAATGAGGCTCAGGACAGTGAAGGAGTGCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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