Basic Information
VIS ID
TVIS44022389
Fusion event
HTLV-1-CXXC5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
139031601/139652016 (Hg38)
End
139031601/139652016 (Hg38)
Orient
+
Location type
Intronic
Target gene
CXXC5
miRNAs that regulate target gene
hsa-mir-9-5p ; hsa-mir-324-3p ; hsa-mir-3907 ; hsa-mir-7106-3p ; hsa-mir-3182 ; hsa-mir-4679 ; hsa-mir-4677-3p ; hsa-mir-548q ; hsa-mir-4469 ; hsa-mir-1237-3p ; hsa-mir-5088-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-6756-3p ; hsa-mir-3127-3p
Nearest miRNA
hsa-mir-10397/Upstream/2004367; hsa-mir-103a-1/Downstream/911655;
Nearest TSS
ENST00000502646/Upstream/1027; ENST00000511591/Downstream/7539;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1382, chr5-CpG: 23/Downstream/9143
Nearest cancer related gene
CXXC5(TSG, No orient, 0)
Upstream sequence
TTattcatttgttggcccaatatgtttgtattgagcacctactgtgtatcaaaccccacccttctggtggtacacaaatgaatcactgctccagctctgg
Downstream sequence
aggCAGGCCCAGGATAGAAGCTCCGCCCCGTTTCCCCGCCCCCTGGGGCCCTGATTGGGGCTTTCCCTCTTTTCTTTTTTCTGGGGCTCTCCCTCTCTTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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