Basic Information
VIS ID
TVIS44022401
Fusion event
HTLV-1-STK32A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q32
Reference genome
GRCh37/hg19
Start
146674429/147294866 (Hg38)
End
146674429/147294866 (Hg38)
Orient
+
Location type
Intronic
Target gene
STK32A
miRNAs that regulate target gene
hsa-mir-1262 ; hsa-mir-1273g-3p ; hsa-mir-4252 ; hsa-mir-4522 ; hsa-mir-4701-3p ; hsa-mir-4793-3p ; hsa-mir-4797-5p ; hsa-mir-5001-3p ; hsa-mir-508-5p ; hsa-mir-542-3p ; hsa-mir-5586-3p ; hsa-mir-5694 ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-6720-5p ; hsa-mir-6736-5p ; hsa-mir-6742-3p ; hsa-mir-6776-5p ; hsa-mir-6849-3p ; hsa-mir-759 ; hsa-mir-766-3p ; hsa-mir-7703 ; hsa-mir-873-3p
Nearest miRNA
hsa-mir-10397/Upstream/3614895; hsa-mir-103a-1/Downstream/1767447;
Nearest TSS
ENST00000502646/Upstream/59741; ENST00000503384/Downstream/47607;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/59785, chr5-CpG: 110/Downstream/158131
Upstream sequence
tctgcctcctgggttcaagcaattctcttgcttcagcctcccaagtagctgggactacaggcatgtgccaccacacctggctatttttttgtatttttag
Downstream sequence
gagagacggggtttcactgtgtttgccagggtggtctcgatctcctgaccgcatgatctgcccgcctcggcctcccaaagtgctgggataacaggcatga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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