Basic Information
VIS ID
TVIS44022403
Fusion event
HTLV-1-PPARGC1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q32
Reference genome
GRCh37/hg19
Start
149228334/149848771 (Hg38)
End
149228334/149848771 (Hg38)
Orient
+
Location type
UTR3
Target gene
PPARGC1B
miRNAs that regulate target gene
hsa-mir-423-5p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-186-5p ; hsa-mir-23b-3p ; hsa-mir-3687 ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-214-3p ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-5582-5p ; hsa-mir-6768-5p ; hsa-mir-3692-3p ; hsa-mir-422a ; hsa-mir-378i ; hsa-mir-378h ; hsa-mir-378f ; hsa-mir-378e ; hsa-mir-378d ; hsa-mir-378c ; hsa-mir-378b ; hsa-mir-378a-3p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-361-3p ; hsa-mir-6793-3p ; hsa-mir-499b-5p
Nearest miRNA
hsa-mir-10397/Upstream/115881; hsa-mir-103a-1/Downstream/1673316;
Nearest TSS
ENST00000502646/Upstream/3128; ENST00000433184/Downstream/19121;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/116584, chr5-CpG: 102/Downstream/111597
Upstream sequence
TGTCTGTGCCTGTGGACACACTGTCAGAACTTCAGTGACACCCCTGGCAGCGGTACAGACAGGTGGTCTGGGAGCAGTCATCTTTTTTGGGCCAGCCACC
Downstream sequence
AGCCCATCCTACTCCCTCAGGTAGTCCTTCGTCTTTACCTTGTCCTTGTCTGTAAAGTTGTTTTGGTGGCTGGGGCAGGGGAGCCAGGAGGAGGGAGTGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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