Basic Information
VIS ID
TVIS44022406
Fusion event
HTLV-1-SYNPO integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
149974388/150594826 (Hg38)
End
149974388/150594826 (Hg38)
Orient
+
Location type
Intronic
Target gene
SYNPO
miRNAs that regulate target gene
hsa-mir-4433b-5p ; hsa-mir-1298-5p ; hsa-mir-4433a-5p ; hsa-mir-130b-5p ; hsa-mir-6748-3p ; hsa-mir-339-5p ; hsa-mir-3620-3p ; hsa-mir-330-3p ; hsa-mir-6871-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-6835-3p ; hsa-mir-574-5p ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-4311 ; hsa-mir-4693-3p
Nearest miRNA
hsa-mir-10397/Upstream/861936; hsa-mir-103a-1/Downstream/927261;
Nearest TSS
ENST00000502646/Upstream/42265; ENST00000518872/Downstream/6254;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/66701, chr5-CpG: 23/Downstream/30282
Nearby gene
SYNPO(+6254) ;
Upstream sequence
acaacctggggaggtgggcgtggtgaacattatccccagtttttttcggatgataaaactgaggctcagagatggggaaagtccttccaagtttgcacag
Downstream sequence
caaggtaatggtcgagcaggactcTTGCCGTTCTGTCCAGACCTCCATCAACTGCCCCAGAAGTTTGCAAGGGGCTTCAGTGGGGCCTGGATGCTGTGGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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