Basic Information
VIS ID
TVIS44022417
Fusion event
HTLV-1-ATP10B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q34
Reference genome
GRCh37/hg19
Start
160078992/160651985 (Hg38)
End
160078992/160651985 (Hg38)
Orient
+
Location type
Intronic
Target gene
ATP10B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-mir-10397/Upstream/166535; hsa-mir-103a-1/Downstream/7513860;
Nearest TSS
ENST00000502646/Upstream/17427; ENST00000524198/Downstream/33366;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/229879, chr5-CpG: 68/Downstream/895701
Upstream sequence
TTGTCAGCTGCTTTCATGCCCCTGATTAAGTCATGTGCTTCACTCCTGATCCACACCACTCAGCTCAGTGGTGGGTCTCTAAATCCAAACTCATTTCAGA
Downstream sequence
TATGACTGGCAGTGGGGTCTGAGCACTAATGATCCTTCTGTAATGCCTCGGAGTCCCTGCTGCCTGTTTAATCACACCTGCCGGGCCCCAGCAATGGTGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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