Basic Information
VIS ID
TVIS44022422
Fusion event
HTLV-1-SLIT3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
168439338/169012333 (Hg38)
End
168439338/169012333 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
SLIT3
miRNAs that regulate target gene
hsa-mir-218-2-3p ; hsa-mir-218-5p ; hsa-mir-1343-3p ; hsa-mir-208a-5p ; hsa-mir-208b-5p ; hsa-mir-214-3p ; hsa-mir-24-3p ; hsa-mir-3074-5p ; hsa-mir-3619-5p ; hsa-mir-3690 ; hsa-mir-4254 ; hsa-mir-4291 ; hsa-mir-4511 ; hsa-mir-6077 ; hsa-mir-646 ; hsa-mir-6783-3p ; hsa-mir-7152-5p ; hsa-mir-7-5p ; hsa-mir-761 ; hsa-mir-922
Nearest miRNA
hsa-mir-10397/Upstream/244078; hsa-mir-10523/Downstream/251268;
Nearest TSS
ENST00000502646/Upstream/19333; ENST00000504527/Downstream/894;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/432420, chr5-CpG: 94/Downstream/288092
Upstream sequence
TATTTCCTTCCAGTGTCTCACCAACTGGCAGCCATCCACTTCAGGTGTGCCCGTTGAAGGATGCCACCTCGAAGGAGATGGGACCAGCCTTGTGTTGGGG
Downstream sequence
TGAGGATTCTGGCCACTTGATCTGGGCAGGAGTGCTCTGCTCAGAGTGCAGTGCTCAATCTTACAAGCCTGGCTCGCCTGAACTGTGAAAGGTCAGCAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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