Basic Information
VIS ID
TVIS44022429
Fusion event
HTLV-1-HK3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
176316686/176889685 (Hg38)
End
176316686/176889685 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA5G
Target gene
HK3
Nearest miRNA
hsa-mir-10397/Upstream/260185; hsa-mir-1229/Downstream/2908593;
Nearest TSS
ENST00000502646/Upstream/1038; ENST00000510933/Downstream/1706;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/2024, chr5-CpG: 128/Downstream/116168
Upstream sequence
AGGCCTGCTAGCCAGGCAGCACACCCTCCACCTGTCATCACAAATGGTCCATGGCTCACCTACAACTAGCCCAACCTCACACGGCCTGACCCCCGGCTCA
Downstream sequence
CAGCCCATCATGGTGCCCACTGTGTCGTTCACCACAGCAACCACGTCGATGTTGTAGGCCTAGATGATGAAGAGGGCAGAGGTCAAGGCTGGCCTGAGTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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