Basic Information
VIS ID
TVIS44022453
Fusion event
HTLV-1-EGFLAM integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
38392021/38391919 (Hg38)
End
38392021/38391919 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
EGFLAM
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-5089-5p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-4769-5p ; hsa-mir-4654 ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-4648 ; hsa-mir-4320 ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p
Nearest miRNA
hsa-mir-10397/Upstream/2243931; hsa-mir-103a-1/Downstream/165583;
Nearest TSS
ENST00000502646/Upstream/45368; ENST00000508868/Downstream/11443;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/132885, chr5-CpG: 151/Downstream/164201
Upstream sequence
aggctggactgcagtggcgcaaccttggctcactgcaaactctacctcccaggttcaagtgattcttgtccctcagcctcccgagtagctgggattacag
Downstream sequence
gcgcccaccaccacactcggctaatttttTTttcttttttaacttttattttaggttcagaggtacatgtgaaggtttgttacacagataaacccatgtc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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